Luis Guzman may refer to:

• Luis Enríquez de Guzmán, 9th Count of Alba de Liste (born circa 1605)
• Luis Muñoz de Guzmán (born 1808), Spanish colonial administrator
• Luis Guzmán (born 28 August 1956), Puerto Rican actor
• Luis Roberto Guzmán (born 1966), Puerto Rican actor
• Luis Ernesto Guzmán (born 1980), Honduran footballer

This disambiguation page lists articles associated with the same personal name. If an internal link led you here, you may wish to change the link to point directly to the intended article.